Blog

Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat.

BACKGROUND Notwithstanding growing data of titanium dioxide nanoparticles (TiO2 NPs) passing via organic limitations, their biodistribution to the central nervous system (CNS) and potential results on blood-brain barrier (BBB) physiology stay poorly characterised. METHODS Here, we report time-related responses from single-dose intravenous (IV) administration of 1 mg/kg TiO2 NPs to rats, with explicit emphasis on

Read More
Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles.

It is of curiosity to evaluate the clinical and pathological points of Gallbladder and biliary tract carcinomas confirmed by histological knowledge. It can be of additional curiosity to judge the hyperlink between Helicobacter pylori and biliary tract cancers. Eighty-nine (89) circumstances (imply age 60±12 years) of Gallbladder and biliary tract cancer confirmed by histological knowledge have been

Read More
Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study

Giardia lamblia is a deeply branched zoonotic intestinal protozoan pathogen. It infects humans, causing the diarrheal disease giardiasis, throughout the world (1, 2). Prolonged infections in humans often cause malabsorption of nutrients with weight loss in the absence of treatment, despite an immune response that would be expected to control the infection (3). Both innate

Read More
Development of -Potential Pharmacodynamic and Diagnostic Markers for Anti-IFNα Monoclonal Antibody Trials in Systemic Lupus Erythematosus

To establish potential pharmacodynamic biomarkers to information dose choice in medical trials utilizing anti-interferon-alpha (IFN-α) monoclonal antibody (mAb) remedy for systemic lupus erythematosus (SLE), we used an Affymetrix human genome array platform and recognized 110 IFN-α/β-inducible transcripts considerably upregulated in entire blood (WB) of 41 SLE sufferers. The overexpression of these genes was confirmed prospectively

Read More