MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model.

Ubiquitination-mediated M1/M2 macrophage polarization performs vital roles in the pathogenesis of immune illness. However, the regulatory mechanism of ubiquitination throughout M1/M2 macrophage polarization following intracerebral hemorrhage (ICH) has not been properly studied.In the experiment, macrophages have been administered with erythrocyte lysates, after which miR-494-, Nrdp1-, and M1/M2-related markers have been analyzed. Brain inflammatory response, mind

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