Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat.

BACKGROUND Notwithstanding growing data of titanium dioxide nanoparticles (TiO2 NPs) passing via organic limitations, their biodistribution to the central nervous system (CNS) and potential results on blood-brain barrier (BBB) physiology stay poorly characterised. METHODS Here, we report time-related responses from single-dose intravenous (IV) administration of 1 mg/kg TiO2 NPs to rats, with explicit emphasis on

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